You might get unusual errors about Unicode and inability to convert to ASCII. Programs might just crash at random. Those are often simple to fix — all you need is correct locale configuration.
Setting up Python is usually simple, but there are some places where newcomers (and experienced users) need to be careful. What versions are there? What’s the difference between Python, CPython, Anaconda, PyPy? Those and many other questions may stump new developers, or people wanting to use Python.